Prostaglandin F2α negatively regulates bone resorption in murine osteoclast development

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chapter 3. Osteoclast Biology and Bone Resorption

66. Fuentealba LC, Eivers E, Ikeda A. Hurtado C, Kuroda H, Pera EM, De Robertis E M 2007 Integrating patterning signals: Wnti GSK3 regulates the duration of the BMP/Smadl signal. Cell 13 1 : 980-993. 67. Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J 2007 Balancing BMP signaling through integrated inputs into the Smadl linker. Mol Cell 25:441454. 68. Nakayama K, Tamura Y, Suzawa M,...

متن کامل

MafB negatively regulates RANKL-mediated osteoclast differentiation.

Receptor activator of nuclear factor kappaB ligand (RANKL) induces osteoclast formation from hematopoietic cells via regulation of various transcription factors. Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation. Expression levels of MafB are significantly reduced by RANKL during osteoclastogenesis. Overexpression of MafB in bone marrow-derived monocyte/macro...

متن کامل

The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

OBJECTIVE While phosphoinositide 3-kinases (PI3Ks) are involved in various intracellular signal transduction processes, the specific functions of the different PI3K isoforms are poorly understood. We have previously shown that the PI3Kβ isoform is required for arthritis development in the K/BxN serum-transfer model. Since osteoclasts play a critical role in pathologic bone loss during inflammat...

متن کامل

IkappaBalpha regulates Hes1 in osteoclast differentiation and resorption.

During osteoclast differentiation and resorption, both NF-kappaB and Notch signalling are activated. This study defines the mechanism about the influence of NFkappaB on Notch. To this end, IkappaBalphaM and Wild-type-IkappaBalpha were transfected into RAW 264.7 cells. The number of cells that differentiated into osteoclasts was quantified. The resorption area was measured. NF-kappaB transcripti...

متن کامل

Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis.

Multicentric reticulohistiocytosis (MR) is a systemic disease of unknown cause characterized by the presence of a heavy macrophage infiltrate in skin and synovial tissues and the development of an erosive polyarthritis. The synovial fluid in MR is known to contain numerous mononuclear cells. In this study, we have determined whether these cells contribute to joint destruction in MR by different...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Prostaglandins & Other Lipid Mediators

سال: 2008

ISSN: 1098-8823

DOI: 10.1016/j.prostaglandins.2008.06.002